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肝細胞 Cellartis® Enhanced hiPS-HEP v2 Kit

使用文献

  1. 2Dおよび3Dスフェロイドの両方でhiPS-HEPと初代肝星細胞とを共培養することができ、NASH(非アルコール性脂肪性肝炎)のin vitroモデルを構築した。
    Holmgren, G et al.
    Characterization of Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mature Features and Potential for Modeling Metabolic Diseases.
    Int. J. Mol. Sci. 2020, 21(2).

参考文献

  1. Annika Asplund et al.
    One Standardized Differentiation Procedure Robustly Generates HomogenousHepatocyte Cultures Displaying Metabolic Diversity from a Large Panel of Human Pluripotent Stem Cells.
    Stem Cell Rev. 2016 12(1):90-104.
  2. Nidal, G. et al.
    Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines
    Stem Cells International. 2016 10.1155/2016/8648356.
  3. Ulvestad M et al.
    Drug metabolizing enzyme and transporter protein profi les of hepatocytes derived from human embryonic and induced pluripotent stem cells.
    Biochem Pharmacol. 2013 Sep 1; 86(5):691-702.
  4. Yildirimman R et al.
    Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.
    Toxicol. Sci. 2011 Dec; 124(2): 278-290.
  5. Mantel N et al.
    Potential markers of attenuation of YF virus after infection of stem cell-derived human hepatocytes with wild-type Asibi or live-attenuated YF17D virus.
    Supplement to The American Journal of tropical Medicine and Hygiene, Volume 83, November 2010, Number 5, abstract 12.
  6. Heins et al. Stem Cells 2004; 22: 367-376.
    United States National Stem Cell Bank; http://www.nationalstemcellbank.org

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