Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells.
T Yoshikawa, Y Ito, Z Wu, H Kasuya, T Nakashima, S Okamoto, Y Amaishi, H Zhang, Y Li, T Matsukawa, S Inoue, Y Kagoya Cell Rep Med. 2024 May 21;5(5):101526. doi: 10.1016/j.xcrm.2024.101526.
Evaluation of neprilysin activity in Adipose-Derived stem cells from Alzheimer's disease patients.
K Shigematsu, N Komori, M Ideno, H Yamagishi Neurosci Lett. 2024 Mar 10;825:137705. doi: 10.1016/j.neulet.2024.137705.
Applications and Limitations of Equilibrium Density Gradient Analytical Ultracentrifugation for the Quantitative Characterization of Adeno-Associated Virus Vectors.
K Hirohata, Y Yamaguchi, T Maruno, R Shibuya, T Torisu, T Onishi, H Chono, J Mineno, Y Yuzhe, K Higashiyama, K Masumi-Koizumi, K Uchida, T Yamamoto, E Uchida, T Okada, S Uchiyama Anal Chem. 2024 Jan 16;96(2):642-651. doi: 10.1021/acs.analchem.3c01955.
2023年
Therapy
Exhaustion, rather than lack of infiltration and persistence, of CAR-T cells hampers the efficacy of CAR-T therapy in an orthotopic PDAC xenograft model.
Y Takeuchi, Yizheng Wang 2, K Sasaki, O Sato, T Tsuchikawa, L Wang, Y Amaishi, S Okamoto, J Mineno, Y Hirokawa, K C Hatanaka, Y Hatanaka, T Kato, H Shiku, S Hirano Biomed Pharmacother. 2023 Dec 22;170:116052. doi: 10.1016/j.biopha.2023.116052.
Adipose-derived stem cells' potential in neurodegenerative therapy: Highlighting reelin activity.
K Shigematsu, N Komori, M Ideno, H Yamagishi Medical Hypotheses 2023 Dec 17;182:111226. doi: 10.1016/j.mehy.2023.111226.
Safety and Efficacy of NY-ESO-1 Antigen-Specific T-Cell Receptor Gene-Transduced T Lymphocytes in Patients with Synovial Sarcoma: A Phase I/II Clinical Trial.
A Kawai, M Ishihara, T Nakamura, S Kitano, S Iwata, K Takada, M Emori, K Kato, M Endo, Y Matsumoto, S Kakunaga, E Sato, Y Miyahara, K Morino, S Tanaka, S Takahashi, F Matsuo, A Matsumine, S Kageyama, T Ueda Clin Cancer Res. 2023 Dec 15;29(24):5069-5078. doi: 10.1158/1078-0432.CCR-23-1456.
Repeated intravenous infusion of adipose Tissue-Derived stem cells as a promising treatment for amyotrophic lateral sclerosis.
K Shigematsu, M Ideno, N Komori, H Yamagishi Medical Hypotheses 2023 Nov 4;181:111205. doi: 10.1016/j.mehy.2023.111205.
Evolution of the viral genomes of SARS-CoV-2 in association with the changes in local condition: a genomic epidemiological study of a suburban city of Japan.
Y Kashima, T Mizutani, Y Okimoto, M Maeda, K Musashino, R Nishide, A Matsukura, J Nagase, Y Suzuki DNA Res. 2023 Oct 1;30(5):dsad020. doi: 10.1093/dnares/dsad020.
Pathogen Profiles in Outpatients with Non-COVID-19 during the 7th Prevalent Period of COVID-19 in Gunma, Japan.
H Kimura, Y Hayashi, M Kitagawa, M Yoshizaki, K Saito, K Harada, K Okayama, Y Miura, R Kimura, T Shirai, K Fujita, S Machida, K Ito, I Kurosawa Microorganisms, 2023 Aug 24;11(9):2142. doi: 10.3390/microorganisms11092142.
Intradermal administration of DNA vaccine targeting Omicron SARS-CoV-2 via pyro-drive jet injector provides the prolonged neutralizing antibody production via germinal center reaction.
H Hayashi, J Sun, Y Yanagida, T Otera, J A Tai, T Nishikawa, K Yamashita, N Sakaguchi, S Yoshida, S Baba, C Y Chang, M Shimamura, S Okamoto, Y Amaishi, H Chono, J Mineno, H Rakugi, R Morishita, H Nakagami Sci Rep. 2023 Aug 10;13(1):13033. doi: 10.1038/s41598-023-40172-y.
CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy.
Y Wang, L Wang, N Seo, S Okumura, T Hayashi, Y Akahori, H Fujiwara, Y Amaishi, S Okamoto, J Mineno, Y Tanaka, T Kato, H Shiku Int J Mol Sci. 2023 Jun 29;24(13):10873. doi: 10.3390/ijms241310873.
Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality.
K Ohba, Y Sehara, T Enoki, J Mineno, K Ozawa, H Mizukami iScience, 2023 Mar 23;26(4):106487. doi: 10.1016/j.isci.2023.106487.
Tumor Growth Suppression of Pancreatic Cancer Orthotopic Xenograft Model by CEA-Targeting CAR-T Cells.
O Sato, T Tsuchikawa, T Kato, Y Amaishi, S Okamoto, J Mineno, Y Takeuchi, K Sasaki, T Nakamura, K Umemoto, T Suzuki, L Wang, Y Wang, K C Hatanaka, T Mitsuhashi, Y Hatanaka, H Shiku, S Hirano Cancers (Basel), 2023 Jan 18;15(3):601. doi: 10.3390/cancers15030601.
Glycobiology
Assays and Utilization of Enzymes Involved in Glycolipid Metabolism in Bacteria and Fungi.
K Ohba, Y Sehara, T Enoki, J Mineno, K Ozawa, H Mizukami Methods Mol Biol. 2023 Jan;2613:229-256. doi: 10.1007/978-1-0716-2910-9_18.
2022年
PCR
Establishment of a Direct PCR Assay for Simultaneous Differential Diagnosis of African Swine Fever and Classical Swine Fever Using Crude Tissue Samples.
T Nishi, K Okadera, K Fukai, M Yoshizaki, A Nakasuji, S Yoneyama, T Kokuho Viruses, 2022 Feb 28;14(3):498. doi: 10.3390/v14030498.
Therapy
Metformin enhances the antitumor activity of oncolytic herpes simplex virus HF10 (canerpaturev) in a pancreatic cell cancer subcutaneous model.
M Abdelmoneim, I R Eissa, M A Aboalela, Y Naoe, S Matsumura, P A Sibal, I Bustos-Villalobos, M Tanaka, Y Kodera, H Kasuya Sci Rep. 2022 Dec 13;12(1):21570. doi: 10.1038/s41598-022-25065-w.
Modified DNA vaccine confers improved humoral immune response and effective virus protection against SARS-CoV-2 delta variant.
H Hayashi, J Sun, Y Yanagida, T Otera, M Sasai, C Y Chang, J A Tai, T Nishikawa, K Yamashita, N Sakaguchi, S Yoshida, S Baba, M Shimamura, S Okamoto, Y Amaishi, H Chono, J Mineno, H Rakugi, R Morishita, M Yamamoto, H Nakagami Sci Rep. 2022 Dec 3;12(1):20923. doi: 10.1038/s41598-022-24519-5.
Immune response induced in rodents by anti-CoVid19 plasmid DNA vaccine via pyro-drive jet injector inoculation.
T Nishikawa, C Y Chang, J A Tai, H Hayashi, J Sun, S Torii, C Ono, Y Matsuura, R Ide, J Mineno, M Sasai, M Yamamoto, H Nakagami, K Yamashita Immunol Med. 2022 Aug 24;1(14). doi: 10.1080/25785826.2022.2111905. Online ahead of print.
NY-ESO-1-specific redirected T cells with endogenous TCR knockdown mediate tumor response and cytokine release syndrome.
M Ishihara, S Kitano, S Kageyama, Y Miyahara, N Yamamoto, H Kato, H Mishima, H Hattori, T Funakoshi, T Kojima, T Sasada, E Sato, S Okamoto, D Tomura, I Nukaya, H Chono, J Mineno, M F Kairi, P D H Nguyen, Y Simoni, A Nardin, E Newell, M Fehlings, H Ikeda, T Watanabe, H Shiku Clinical Trial J Immunother Cancer, 2022 Jun;10(6):e003811. doi: 10.1136/jitc-2021-003811.
Preclinical study of a DNA vaccine targeting SARS-CoV-2.
H Hayashi, J Sun, Y Yanagida, T Otera, R Kubota-Koketsu, T Shioda, C Ono, Y Matsuura, H Arase, S Yoshida, R Nakamaru, N Ju, R Ide, A Tenma, S Kawabata, T Ehara, M Sakaguchi, H Tomioka, M Shimamura, S Okamoto, Y Amaishi, H Chono, J Mineno, T Komatsuno, Y Saito, H Rakugi, R Morishita, H Nakagami Curr Res Transl Med. 2022 Apr 20;70(4):103348. doi: 10.1016/j.retram.2022.103348. Online ahead of print.
2021年
Gene Therapy
S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model.
Noriyuki Miyajima, Ibrahim Ragab Eissa, Mohamed Abdelmoneim, Yoshinori Naoe, Toru Ichinose, Shigeru Matsumura, Itzel Bustos-Villalobos, Nobuaki Mukoyama, Daishi Morimoto, Masahiro Shibata, Dai Takeuchi, Nobuyuki Tsunoda, Toyone Kikumori, Maki Tanaka, Yasuhiro Kodera, Hideki Kasuya., Nagoya J Med Sci. 2021 Nov;83(4):683-696. doi: 10.18999/nagjms.83.4.683.
Repeated infusion of autologous adipose tissue-derived stem cells for Parkinson's disease.
Kazuo Shigematsu, Naoyuki Komori, Kenichi Tahara, Hisakazu Yamagishi., Acta Neurol Scand. 2022 Jan;145(1):119-122. doi: 10.1111/ane.13547. Epub 2021 Oct 29.
C-REV Retains High Infectivity Regardless of the Expression Levels of cGAS and STING in Cultured Pancreatic Cancer Cells.
Daishi Morimoto, Shigeru Matsumura, Itzel Bustos-Villalobos, Patricia Angela Sibal, Toru Ichinose, Yoshinori Naoe, Ibrahim Ragab Eissa, Mohamed Abdelmoneim, Nobuaki Mukoyama, Noriyuki Miyajima, Maki Tanaka, Yasuhiro Kodera, Hideki Kasuya., Cells. 2021 Jun 15;10(6):1502. doi: 10.3390/cells10061502.
Comparison of predictors for terminal disease progression in simian immunodeficiency virus/simian-HIV-infected rhesus macaques.
Naofumi Takahashi, Amir Ardeshir, Gerard E Holder, Yanhui Cai, Chie Sugimoto, Kazuyasu Mori, Mariluz Araínga, Ziyuan He, Yayoi Fukuyo, Woong-Ki Kim, Elizabeth S Didier, Marcelo J Kuroda., Biol Blood Marrow Transplant. AIDS. 2021 Jun 1;35(7):1021-1029. doi: 10.1097/QAD.0000000000002874.
Next-Generation Sequencing Analysis
Validation and standardization of DNA extraction and library construction methods for metagenomics-based human fecal microbiome measurements.
Dieter M Tourlousse, Koji Narita, Takamasa Miura, Mitsuo Sakamoto, Akiko Ohashi, Keita Shiina, Masami Matsuda, Daisuke Miura, Mamiko Shimamura, Yoshifumi Ohyama, Atsushi Yamazoe, Yoshihito Uchino, Keishi Kameyama, Shingo Arioka, Jiro Kataoka, Takayoshi Hisada, Kazuyuki Fujii, Shunsuke Takahashi, Miho Kuroiwa, Masatomo Rokushima, Mitsue Nishiyama, Yoshiki Tanaka, Takuya Fuchikami, Hitomi Aoki, Satoshi Kira, Ryo Koyanagi, Takeshi Naito, Morie Nishiwaki, Hirotaka Kumagai, Mikiko Konda, Ken Kasahara, Moriya Ohkuma, Hiroko Kawasaki, Yuji Sekiguchi, Jun Terauchi., Microbiome. 2021 Apr 29;9(1):95. doi: 10.1186/s40168-021-01048-3.
Stem Cells
Long-term survival of a patient with amyotrophic lateral sclerosis (ALS) who received autologous adipose-derived mesenchymal stem cells.
K Shigematsu, T Takeda, N Komori, N Urushihata, K Oki, K Tahara, H Yamagishi., Eur Rev Med Pharmacol Sci. 2021 Jun;25(11):4086-4090. doi: 10.26355/eurrev_202106_26050.
Hypothesis: Intravenous administration of mesenchymal stem cells is effective in the treatment of Alzheimer's disease.
Kazuo Shigematsu, Takahisa Takeda, Naoyuki Komori, Kenichi Tahara, Hisakazu Yamagishi., Case Reports Med Hypotheses. 2021 May;150:110572. doi: 10.1016/j.mehy.2021.110572. Epub 2021 Mar 23.
2020年
Gene Therapy
Induction of E. coli-derived endonuclease MazF suppresses HIV-1 production and causes apoptosis in latently infected cells.
Mika Okamoto, Hideto Chono, Akemi Hidaka, Masaaki Toyama, Junichi Mineno, Masanori Baba., Biochem Biophys Res Commun. 2020 Sep 24;530(3):597-602. doi: 10.1016/j.bbrc.2020.07.103. Epub 2020 Aug 1.
Development of a Unique T Cell Receptor Gene-Transferred Tax-Redirected T Cell Immunotherapy for Adult T Cell Leukemia.
Kawamura K, Tanaka Y, Nakasone H, Ishihara Y, Kako S, Kobayashi S, Tanaka Y, Ohmori T, Uchimaru K, Okamoto S, Mineno J, Shiku H, Nishimura S, Kanda Y., Biol Blood Marrow Transplant. 2020 Aug;26(8):1377-1385.doi:10.1016/j.bbmt.2020.04.006. Epub 2020 Apr 18.
Next-Generation Sequencing Analysis
Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor-infiltrating cells.
Sato Y, Wada I, Odaira K, Hosoi A, Kobayashi Y, Nagaoka K, Karasaki T, Matsushita H, Yagi K, Yamashita H, Fujita M, Watanabe S, Kamatani T, Miya F, Mineno J, Nakagawa H, Tsunoda T, Takahashi S, Seto Y, Kakimi K., Clin Transl Immunology. 2020 Oct 17;9(10):e1194. doi: 10.1002/cti2.1194. eCollection 2020.
Changes in the Gut Microbiota are Associated with Hypertension, Hyperlipidemia, and Type 2 Diabetes Mellitus in Japanese Subjects.
Takagi T, Naito Y, Kashiwagi S, Uchiyama K, Mizushima K, Kamada K, Ishikawa T, Inoue R, Okuda K, Tsujimoto Y, Ohnogi H, Itoh Y., Nutrients. 2020 Sep 30;12(10):2996. doi: 10.3390/nu12102996.
Detection of MEAF6-PHF1 translocation in an endometrial stromal nodule.
Nomura Y, Tamura D, Horie M, Sato M, Sasaki S, Yamamoto Y, Kudo-Asabe Y, Umakoshi M, Koyama K, Makino K, Takashima S, Imai K, Minamiya Y, Munakata S, Yachida S, Terada Y, Goto A, Maeda D., Genes Chromosomes Cancer 2020 Dec 59(12),702-708. 2020 Aug 20. doi: 10.1002/gcc.22892. Online ahead of print.
Stem Cells
miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro.
Ishikawa M, Aoyama T, Shibata S, Sone T, Miyoshi H, Watanabe H, Nakamura M, Morota S, Uchino H, A S Yoo, Okano H., Cells 2020 Feb 25;9(3):532. doi: 10.3390/cells9030532.
2019年
Gene Therapy
Infectivity assessment of recombinant adeno-associated virus (rAAV) and wild-type AAV (wtAAV) exposed to various diluents and environmental conditions. Tomono T, Hirai Y, Chono H, Mineno J, Ishii A, Onodera M, Tamaoka A, Okada T., Hum Gene Ther Methods. 2019 Aug; 30(4):137-143. doi: 10.1089/hgtb.2019.082.
Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation. Sone T, Shin M, Ouchi T, Sasanuma H, Miyamoto A, Ohte S, Tsukamoto S, Nakanishi M, Okano H, Katagiri T, Mitani K., Sci Rep. 2019 Jul 4; 9(1):9705. doi: 10.1038/s41598-019-46105-y.
Combination of Cetuximab and Oncolytic Virus Canerpaturev Synergistically Inhibits Human Colorectal Cancer Growth. Wu Z, Ichinose T, Naoe Y, Matsumura S, Villalobos IB, Eissa IR, Yamada S, Miyajima N, Morimoto D, Mukoyama N, Nishikawa Y, Koide Y, Kodera Y, Tanaka M, Kasuya H., Mol Ther Oncolytics. 2019 May 13; 13:107-115. doi: 10.1016/j.omto.2019.04.004. eCollection 2019 Jun 28.
Highly efficient genome editing for single-base substitutions using optimized ssODNs with Cas9-RNPs.
Okamoto S, Amaishi Y, Maki I, Enoki T, Mineno J. Sci. Rep. 2019 Mar 18; 9(1):4811. doi: 10.1038/s41598-019-41121-4.
Next-Generation Sequencing Analysis
Gut microbiota differences in elderly subjects between rural city Kyotango and urban city Kyoto: an age-gender-matched study.
Naito Y, Takagi T, Inoue R, Kashiwagi S, Mizushima K, Tsuchiya S, Itoh Y, Okuda K, Tsujimoto Y, Adachi A, Maruyama N, Oda Y, Matoba S., J Clin Biochem Nutr. 2019 Sep; 65(2):125-131. doi: 10.3164/jcbn.19-26. Epub 2019 Aug 9.
2018年
Gene Therapy
Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor.
Uchibori R, Teruya T, Ido H, Ohmine K, Sehara Y, Urabe M, Mizukami H, Mineno J, Ozawa K. Mol. Ther. Oncolytics. 2018 Dec 1; 12:16-25. doi: 10.1016/j.omto.2018.11.003. eCollection 2019 Mar 29.
Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 9.
Tomono T, Hirai Y, Okada H, Miyagawa Y, Adachi K, Sakamoto S, Kawano Y, Chono H, Mineno J, Ishii A, Shimada T, Onodera M, Tamaoka A, Okada T. Mol. Ther. Methods Clin. Dev. 2018 Nov 1; 11:180-190. doi: 10.1016/j.omtm.2018.10.015. eCollection 2018 Dec 14.
The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers.
Eissa IR, Bustos-Villalobos I, Ichinose T, Matsumura S, Naoe Y, Miyajima N, Morimoto D, Mukoyama N, Zhiwen W, Tanaka M, Hasegawa H, Sumigama S, Aleksic B, Kodera Y, Kasuya H., Cancers (Basel). 2018 Sep 26;10(10). pii: E356. doi: 10.3390/cancers10100356.
Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination.
Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H, Maki T, Fujiwara H, Akatsuka Y, Kato T, Shiku H., Blood. 2018 Sep 13;132(11):1134-1145. doi: 10.1182/blood-2017-08-802926. Epub 2018 Jul 25.
Reprogramming human T cell function and specificity with non-viral genome targeting.
Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A., Nature. 559(7714):405-409. doi: 10.1038/s41586-018-0326-5
Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials.
Hirooka Y, Kasuya H, Ishikawa T, Kawashima Hi, Ohno E, Villalobos Itzel B, Naoe Y, Ichinose T, Koyama N, Tanaka M, Kodera Y, Goto H,., BMC Cancer. 2018 May 25; 18(1):596. doi: 10.1186/s12885-018-4453-z
TCR deep sequencing of transgenic RAG-1-deficient mice reveals endogenous TCR recombination: a cause for caution.
McGuire HM, Watkins TS, Field M, Taylor S, Yasuyama N, Farmer A, Miles JJ, Fazekas de St Groth B., Immunology and Cell Biology. 2018 May 24; 96(6):642-645. doi: 10.1111/imcb.12033
AgriBio
婦人科系癌の既往等を有する女性を対象としたガゴメ昆布フコイダンの安全性ならびに免疫機能への効果
（The Safety and Immune-efficacy of Fucoidan from Gagome Kombu (Kjellmaniella crassifolia) on Women with the History of Gynecological Cancer ）
許 鳳浩, 橋本 慎太郎, 小池 浩司, 上馬塲 和夫, 大野木 宏, 鈴木 信孝., 日本補完代替医療学会誌. 2018 Mar 31; 15(1):29-35.
2017年
Gene Therapy
Safety and persistence of WT1-specific T-cell receptor gene-transduced lymphocytes in patients with AML and MDS.
Tawara I, Masuya M, Katayama N, Kageyama S, Miyahara Y, Shiku H, Fujiwara H, Tanimoto K, Yasukawa M, Nishida T, Terakura S, Murata M, Naoe T, Akatsuka Y, Inaguma Y, Emi N, Ikeda H, Inoue N, Kidokoro T, Okamoto S, Tomura D, Chono H, Nukaya I, Mineno J., Blood. 2017 Nov 2; 130(18):1985-1994.
Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials.
Eissa I, Naoe Y, Bustos-Villalobos I, Ichinose T, Zhiwen W, Kasuya H, Morimoto T, Kodera Y, Tanaka M, Mukoyama N, Miyajima N, Hasegawa H, Sumigama S, Aleksic B., Frontiers in oncology. 2017 Jul 14; 7:Article 149. doi: 10.3389/fonc.2017.00149
Curative effect of HF10 on liver and peritoneal metastasis mediated by host antitumor immunity.
Hotta Y, Kasuya H, Bustos I, Naoe Y, Ichinose T, Tanaka M, Kodera Y., Oncolytic Virother. 2017 Mar 13; 6:31-38. doi: 10.2147/OV.S127179. eCollection 2017.
AgriBio
The influence of long-term use of proton pump inhibitors on the gut microbiota: An age-sex-matched case-control study.
Takagi T, Naito Y, Kashiwagi S, Uchiyama K, Mizushima K, Tsuchiya S, Okayama T, Dohi O, Yoshida N, Kamada K, Ishikawa T, Handa O, Konishi H, Itoh Y, Inoue R, Okuda K, Tsujimoto Y, Ohnogi H., Journal of Clinical Biochemistry and Nutrition. 2017 Dec 12; 62(1):100-105.
Agaro-Oligosaccharides Regulate Gut Microbiota and Adipose Tissue Accumulation in Mice.
Higashimura Y, Takagi T, Mizushima K, Naito Y, Baba Y, Inoue R, Ohnogi H, Honda A, Matsuzaki Y., Journal of nutritional science and vitaminolog. 2017 Oct 6; 63(4):269-276.
2016年
PCR
鼻科基礎研究ハンズオンセミナーの取り組み(第2報)
Kanda A, Noyama Y, Yun Y, Kashima A, Takeno S, Okano M, Izumi K, Ohba T, Kobayashi Y, Tomoda K, Fujieda S, Hirakawa K, Kawauchi H., 日本鼻科学会会誌(Web) . 2016 Jul 23; 55(2):176-185.
Enzyme
Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea.
Ishino S, Nishi Y, Oda S, Yamagami T, Ishino Y, Uemori T, Sagara T, Takatsu N, Shirai T., Nucleic acids research. 2016 Mar 21; 44(7):2977-2986.
Protein Engineering
Sequential formation of two branched intermediates during protein splicing of class three inteins.
Tori K, Perler F., Extremophiles : Microbial Life Under Extreme Conditions. 2016 Oct 4; 21(1):41-49.
Gene Therapy
Efficient tumor regression by adoptively transferred CEA-specific CAR-T cells associated with symptoms of mild cytokine release syndrome.
Wang L, Ma N, Okamoto S, Amaishi Y, Sato E, Seo N, Mineno J, Takesako K, Kato T, Shiku H., OncoImmunology. 2016 Sep 1; 5(9):e1211218.
A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy.
Casey Nicholas Paul, Fujiwara Hiroshi, Tanimoto Kazushi, Yasukawa Masaki, Okamoto Sachiko, Mineno Junichi, Kuzushima Kiyotaka, Shiku Hiroshi., PLOS ONE. 2016 Jun 7; 11(6):e0156896.
Development of engineered T cells expressing a chimeric CD16-CD3ζ receptor to improve the clinical efficacy of mogamulizumab therapy against adult T cell leukemia.
Tanaka H, Fujiwara H, Casey N, Yasukawa M, Ochi F, Tanimoto K, Okamoto S, Mineno J, Kuzushima K, Shiku H Barrett J., Clinical cancer research. 2016 Sep 1; 22(17):4405-4416.
CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.
Nakatsugawa M, Rahman M, Yamashita Y, Ochi T, Wnuk P, Tanaka S, Chamoto K, Kagoya Y, Saso K, Guo T, Hirano N, Wnuk P, Anczurowski M, Butler Marcus O., Scientific reports. 2016 Mar 31;6:23821.
AgriBio
Protective effect of agaro-oligosaccharides on gut dysbiosis and colon tumorigenesis in high-fat diet-fed mice.
Higashimura Y, Naito Y, Takagi T, Uchiyama K, Mizushima K, Ushiroda C, Yoshikawa T, Ohnogi H, Kudo Y, Yasui M, Inui S, Hisada T, Honda A, Matsuzaki Y., American journal of physiology. Gastrointestinal and liver physiology. 2016 Mar 15; 310(6):G367-G375.
2015年
Real-Time RT-PCR
Detection of legionella species in environmental water by the quantitative pcr method in combination with ethidium monoazide treatment.
Inoue H, Takama T, Agata K, Yoshizaki M, Biocontrol Science. 2015 Mar 30;20(1):71-74.
Stem Cells
Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors.
Ishikawa T, Kobayashi M, Yanagi S, Kato C, Takashima R, Kobayashi E, Hagiwara K, Ochiya T., PloS one. 2015 Apr 13;10(4):e0123193.
Gene Therapy
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
Matsuzaki J, Tsuji T, Odunsi K, Old Lloyd J, Gnjatic S, Luescher I, Shiku H, Mineno J, Okamoto S, Shrikant P., Scientific reports. 2015 Oct 8;5:14896.
Donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene: detailed immunological function following add-back after haplo-identical transplantation.
Hashimoto H, Ueda R, Kitano S, Yamagata S, Ito A, Fuji S, Yamashita T, Fukuda T, Miyagi Maeshima A, Tada K, Tomura D, Nukaya I, Mineno J, Mori S, Takaue Y, Heike Y., Cytotherapy. 2015 Oct 6;17(12):1820-1830.
Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer.
Sakamoto N, Ishikawa T, Kokura S, Okayama T, Oka K, Naito Y, Itoh Y, Yoshikawa T, Ideno M, Sakai F, Kato A, Tanabe M, Enoki T, Mineno J., Journal of translational medicine. 2015 Aug 25;13:277.
Differentiation kinetics of blood monocytes and dendritic cells in macaques: Insights to understanding human myeloid cell development.
Sugimoto C, Hasegawa A, Saito Y, Fukuyo Y, B. Chiu K, Cai Y, Kuroda M, Breed M, Lackner A, Mori K, Roy C, Didier E, Kim W., Journal of immunology. 2015 Jul 15;195(4):1774-1781.
Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.
Fujiwara H, Ochi T, Ochi F, Miyazaki Y, Asai H, Yasukawa M, Narita M Okamoto S, Mineno J, Kuzushima K, Shiku H., Leukemia. 2015 Jun 24;29(12):2393-2401.
Erratum to:
Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Hashimoto H,; Ueda R, Kitano S, Tada K, Ito A, Fuji S, Kim S, Yamashita T, Fukuda T, Tomura D, Nukaya I, Mineno J, Mori S, Takaue Y, Heike Y., International journal of hematology. 2015 Sep 11;102(4):506.
Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Hashimoto H, Ueda R, Kitano S, Tada K, Ito A, Fuji S, Yamashita T, Fukuda T, Tomura D, Nukaya I, Mineno J, Mori S, Takaue Y, Heike Y., International Journal of Hematology. 2015 May 7;102(1):101-110.
Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy.
Ochi T, Nakatsugawa M, Chamoto K, Yamashita Y, Tanaka S, Guo T, Hirano N, Fujiwara H, Yasukawa M, Butler M., Cancer immunology research. 2015 May 5;3(9):1070-1081.
Outcomes in Two Japanese Adenosine Deaminase-Deficiency Patients Treated by Stem Cell Gene Therapy with No Cytoreductive Conditioning.
Otsu M, Yamada M, Hatano N, Toita N, Takezaki S, Okura Y, Kobayashi R, Matsumoto Y, Kawamura N, Sakiyama Y, Ariga T, Nakajima S, Kida M, Maeyama Y, Tatsuzawa O, Onodera M, Tsuchida F, Kato, S, Kitagawa M, Mineno J, Hershfield M, Bali P, Candotti F., Journal of Clinical Immunology. 2015 Apr 15;35(4):383-398.
Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer.
Kageyama S, Ikeda H, Miyahara Y, Imai N, Sugino S, Shiku H, Ishihara M, Saito K, Ueda S, Ishikawa T, Kokura S, Naota H, Ohishi K, Shiraishi T, Inoue N, Tanabe M, Kidokoro T, Yoshioka H, Tomura D, Nukaya I, Mineno J, Takesako K., Clinical cancer research. 2015 Apr 8;21(10):2268-2277.
がん免疫細胞療法開発への企業側の取り組み
峰野純一 月刊腫瘍内科. 2015 Mar 28;15(3):315-319.
Specific roles of each TCR hemichain in generating functional chain-centric TCR.
Nakatsugawa M, Yamashita Y, Ochi T, Chamoto K, Tanaka S, Guo T, Hirano N, Butler M., Journal of immunology. 2015 Feb 20;194(7):3487-3500.
AgriBio
ガゴメ昆布由来フコイダンの健常成人の免疫機能への有効性ならびに安全性の評価
( Immune Efficacy and Safety of Fucoidan Extracted from Gagome Kombu (Kjellmaniella crassifolia) in Healthy Japanese Subjects)
大野木宏, 東村泰希, 吉川敏一, 内藤裕二, 宇野賀津子., 日本補完代替医療学会誌. 2015 Dec 25;12(2):87-93.
2014年
RetroNectin
Phase I Clinical Trial of Fibronectin CH296-Stimulated T Cell Therapy in Patients with Advanced Cancer.
Ishikawa T, Kokura S, Enoki T, Sakamoto N, Okayama T, Ideno M, Mineno J, Uno K, Yoshida N, Kamada K, Katada K, Uchiyama K, Handa O, Takagi T, Konishi H, Yagi N, Naito Y, Itoh Y, Yoshikawa T, PLoS One. 2014 Jan 31;9(1):e83786.
An Efficient Large-Scale Retroviral Transduction Method Involving Preloading the Vector into a RetroNectin-Coated Bag with Low-Temperature Shaking.
Dodo K, Chono H, Saito N, Tanaka Y, Tahara K, Nukaya I, Mineno J., PLoS One. 2014 Jan 15;9(1):e86275.
Gene Therapy
Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein.
Earley Lauriel F, Kawano Y, Adachi K, Sun X, Dai M, Nakai H., Journal of virology. 2014 Dec 31;89(6):3038-3048.
The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies.
Tsukahara T, Uchibori R, Iwase N, Urabe M, Mizukami H, Kume A, Kawakami K, Iwasaki M, Yamamoto C, Ohmine K, Teruya T, Ido H, Saga Y, Nakamura M, Brentjens R, Ozawa K., Gene therapy. 2014 Nov 27;22(2):209-215.
キメラ型CD16‐CD3ζ受容体を発現させた遺伝子改変ヒトα/β‐T細胞の抗腫瘍抗体療法への応用
(Gene-modified human α/β-T cells expressing a chimeric CD16-CD3ζ receptor as adoptively transferable effector cells for anticancer monoclonal antibody therapy)
OCHI F, ISHII E, FUJIWARA H, TANIMOTO K, MIYAZAKI Y, ASAI H, YASUKAWA M, OKAMOTO S, MINENO J, KUZUSHIMA K, SHIKU H, BARRETT J., 日本小児血液・がん学会雑誌. 2014 Oct 31;51(4):227.
Combination therapy of oncolytic herpes simplex virus HF10 and bevacizumab against experimental model of human breast carcinoma xenograft.
Tan G, Kasuya H, Sahin T, Yamamura K, Wu Z, Koide Y, Hotta Y, Shikano T, Yamada S, Kanzaki A, Fujii T, Sugimoto H, Nomoto S, Nishikawa Y, Tsurumaru N, Kuwahara T, Fukuda S, Ichinose T, Takeda S, Nakao A, Kodera Y, Tanaka M, Kikumori T., International Journal of Cancer. 2014 Sep 27;7:1718-1730.
Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor.
Ishihara M, Seo N, Muraoka D, Ikeda H, Shiku H, Mitsui J, Tanaka M, Mineno J., PloS one. 2014 Aug 8;9(8):e104669.
CD4+ T cells modified by the endoribonuclease MazF are safe and can persist in SHIV-infected rhesus macaques.
Saito N, Chono H, Mineno J, Shibata H, Ageyama N, Yasutomi Y., Molecular Therapy - Nucleic Acids. 2014 Jun 10;3(6):e618.
Stimulation through very late antigen-4 and -5 improves the multifunctionality and memory formation of CD8+ T cells. European Journal of Immunology. 2014 May 11;44(6):1747-1758.
Combination treatment of human pancreatic cancer xenograft models with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib and oncolytic herpes simplex virus hf10.
Yamamura K, Kasuya H, Sahin T, Tan G, Hotta Y, Tsurumaru N, Fukuda S, Kanda M, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y, Tanaka M., Annals of Surgical Oncology. 2014 Feb 20;21(2):691-698.
Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing.
Adachi K, Enoki T, Kawano Y, Veraz M, Nakai H., Nat. Commun. 2014 Jan 17;5:3075.
AgriBio
Preventive effect of agaro-oligosaccharides on non-steroidal anti-inflammatory drug-induced small intestinal injury in mice.
Higashimura Y, Naito Y, Takagi T, Tanimura Y, Mizushima K, Harusato A, Fukui A, Yoriki H, Handa O, Ohnogi H, Yoshikawa T., Journal of Gastroenterology and Hepatology . 2014 Feb 1;29(2):310-317.
2013年
Gene Therapy
Development of a novel redirected T cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.
Miyazaki Y, Fujiwara H, Asai H, Ochi F, Ochi T, Azuma T, Ishida T, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M., Blood. 2013 121(24),4894-4901.
Adoptive transfer of genetically modified Wilms' tumor 1-specific T cells in a novel malignant skull base meningioma model.
Iwami K, Natsume A, Ohno M, Ikeda H, Mineno J, Nukaya I, Okamoto S, Fujiwara H, Yasukawa M, Shiku H, Wakabayashi T., Neuro Oncol. 2013 Jun;15(6):747-758.
Sustained inhibition of HIV-1 replication by conditional expression of the E. coli-derived endoribonuclease MazF in CD4+ T cells.
Okamoto M, Chono H, Kawano Y, Saito N, Tsuda H, Inoue K, Kato I, Mineno J, Baba M., Hum Gene Ther Methods. 2013 Apr;24(2):94-103.
Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.
Asai H, Fujiwara H, An J, Ochi T, Miyazaki Y, Nagai K, Okamoto S, Mineno J, Kuzushima K, Shiku H, Inoue H, Yasukawa M., PLoS One. 2013;8(2):e56820.
Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: potential utility for adoptive immunotherapy.
Liu B, Ohishi K, Orito Y, Nakamori Y, Nishikawa H, Ino K, Suzuki K, Matsumoto T, Masuya M, Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N., Exp Hematol. 2013 Apr;41(4):367-76.e1.
2012年
Gene Therapy
A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression.
Okamoto S, Amaishi Y, Goto Y, Ikeda H, Fujiwara H, Kuzushima K, Yasukawa M, Shiku H, Mineno J., Mol Ther Nucleic Acids. 2012 Dec 18;1:e63.
HLA-restricted presentation of WT1 tumor antigen in B-lymphoblastoid cell lines established using a maxi-EBV system.
Kanda T, Ochi T, Fujiwara H, Yasukawa M, Okamoto S, Mineno J, Kuzushima K, Tsurumi T., Cancer Gene Ther. (2012) 8:566-571,
Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective anti-leukemia reactivity.
Nagai K, Ochi T, Fujiwara H, An J, Shirakata T, Mineno J, Kuzushima K, Shiku H, Melenhorst JJ, Gostick E, Price DA, Ishii E, Yasukawa M., Blood. (2012) 119:368-376,
T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γc(null) mice.
Shirakura Y, Mizuno Y, Wang L, Imai N, Amaike C, Sato E, Ito M, Nukaya I, Mineno J, Takesako K, Ikeda H, Shiku H., Cancer Sci. (2012) 103:17-25
siRNA-mediated silencing of PD-1 ligands enhances tumor-specific human T-cell effector functions.
Iwamura K, Kato T, Miyahara Y, Naota H, Mineno J, Ikeda H, Shiku H., Gene Therapy 2012,19(10), 959-966.
AgriBio
Anti-tumor-Promoting Activities of Agaro-Oligosaccharides on Two-Stage Mouse Skin Carcinogenesis.
Enoki T, Tominaga T, Takashima F, Ohnogi H, Sagawa H, Kato I. Biol. Pharm. Bull. (2012), 35(7), 1145-1149.
Angelica keiskei Extract Improves Insulin Resistance and Hypertriglyceridemia in Rats Fed a High-Fructose Drink.
Hiromu Ohnogi [Reprint Author], Shoko Hayami, Yoko Kudo, Suzu Deguchi, Shigetoshi Mizutani, Tatsuji Enoki, Yuko Tanimura, Wataru Aoi, Yuji Naito, Ikunoshin Kato, Toshikazu Yoshikawa, Bioscience Biotechnology and Biochemistry May 2012, Vol.76 (5) p928-932.
Six New Chalcones from Angelica keiskei Inducing Adiponectin Production in 3T3-L1 Adipocytes.
Hiromu Ohnogi [Reprint Author]; Yoko Kudo, Kenichi Tahara, Katsumi Sugiyama, Tatsuji Enoki, Shoko Hayami, Hiroaki Sagawa, Yuko Tanimura, Wataru Aoi, Yuji Naito, Ikunoshin Kato, Toshikazu Yoshikawa, Bioscience Biotechnology and Biochemistry May 2012, Vol.76 (5) p961-966.
2011年
Real-Time RT-PCR (Japanese)
Detection and Quantitation of Norovirus Genome Using Real-Time RT-PCR.
Masashi Fujii, Junko Yamamoto, Hiroyuki Mukai, Masahiro Fujita, Hiroyuki Tsukagoshi, Masakazu Yoshizumi, Mika Saito, Kunihisa Kozawa, and Hirokazu Kimura., Japanese Journal of Food Microbiology June 2011, Vol.28 (2) p139-142.
Plants
Alteration of fruit characteristics in transgenic tomatoes with modified expression of a xyloglucan endotransglucosylase/hydrolase gene.
Toshiharu Ohba, Shuichi Takahashi, Kiyozo Asada., Plant Biotechnology March 2011, Vol.28 (1) p25-32.
RetroNectin
Optimization of lentiviral vector transduction into peripheral blood mononuclear cells in combination with the fibronectin fragment CH-296 stimulation.
Chono H, Goto Y, Tanaka S, Tosaka Y, Nukaya I, Mineno J., The Journal of Biochemistry March 2011, Vol.149 (3) p285-292.
Gene Therapy
Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked anti-leukemia reactivity and safety.
Ochi T, Fujiwara H, Okamoto S, An J, Nagai K, Shirakata T, Mineno J, Kuzushima K, Shiku H, Yasukawa M., Blood. (2011) 118:1495-1503.
Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response.
Takahara A, Koido S, Ito M, Nagasaki E, Sagawa Y, Iwamoto T, Komita H, Ochi T, Fujiwara H, Yasukawa M, Mineno J, Shiku H, Nishida S, Sugiyama H, Tajiri H, Homma S., Cancer Immunol Immunother. (2011) 60:1289-1297.
Activation of T-cell receptor signaling in peripheral T-cell lymphoma cells plays an important role in the development of lymphoma-associated hemophagocytosis.
An J, Fujiwara H, Suemori K, Niiya T, Azuma T, Tanimoto K, Ochi T, Akatsuka Y, Mineno J, Ozawa H, Ishikawa F, Kuzushima K, Yasukawa M, Int J Hematol. (2011) 93: 176-185.
In Vivo Safety and Persistence of Endoribonuclease Gene-Transduced CD4+ T Cells in Cynomolgus Macaques for HIV-1 Gene Therapy Model.
Chono H, Saito N, Tsuda H, Shibata H, Ageyama N, et al., PLoS ONE August 2011, Vol.6 (8): e23585. doi:10.1371/journal.pone.0023585
Acquisition of HIV-1 Resistance in T Lymphocytes Using an ACA-Specific E. coli mRNA Interferase.
Chono H, Matsumoto K, Tsuda H, Saito N, Lee K, Kim S, Shibata H, Ageyama N., Terao K, Yasutomi Y, Mineno J, Kim S, Inouye M, Kato I., Human Gene Therapy January 2011, Vol.22 (1) p35-43.
2010年
AgriBio
Oligosaccharides form agar inhibit pro-inflammatory mediators release by Inducing heme oxygenase 1.
Enoki T, Okuda S, Kudo Y, Takashima F, Sagawa H, Kato I., Biosci. Biotechnol. Biochem Vol.74 p766-770.
Antioxidant activity of pigments from sake lees fermented with mushroom.
Kamon T, Kajibe T, Takashima C, Matsui T, Otsuki I, Taguchi M, Tabata M., mushroom science and biotechnology Vol.18 p107-110.
Anti-diabetic Activities of Chalcones Derived from Ashitaba.
Enoki T, Sagawa H, Kobayashi E, Onogi H. Journal of the Japanese Society for Food Science and Technology Vol.57 p456-463.
2009年
Gene Therapy
Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogenous TCR
Okamoto S, Mineno J, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, and Kato I., Cancer Research Vol.69 p9003-9011.
Rapid αβ TCR-mediated responses in γδ T cells transduced with cancer-specific TCR genes.
Hiasa A, Nishikawa H, Hirayama M, Kitano S, Okamoto S, Chono H, Yu SS, Mineno J, Tanaka Y, Minato N, Kato I, Shiku H., Gene therapy Vol.16 (5) p620-628.
ISSN : 0969-7128_(print) 1476-5462_(electronic)
Glycobiology
High levels of E4-PHA-reactive oligosaccharides: potential as marker for cells with characteristics of hepatic progenitor cells.
Sasaki N, Moriwaki K, Uozumi N, Noda K, Taniguchi N, Kameyama A, Narimatsu H, Takeishi S, Yamada M, Koyama N, Miyoshi E., Glycoconj J Vol.26, p1213-1223.
Plants
ARTRA：a new database of the Arabidopsis transcriptome and gene-specific sequences for microarray probes and RNAi triggers.
Ohba Toshiharu, et al., Plant Biotechnology Vol.26, p161-165.
2008年
Gene Therapy
Long-term phenotypic, functional and genetic stability of cancer-specific T-cell receptor (TCR) alphabeta genes transduced to CD8+ T cells.
Hiasa A, Hirayama M, Nishikawa H, Kitano S, Nukaya I, Yu SS, Mineno J, Kato I, Shiku H., Gene therapy Vol.15 (9) p695-699.
ISSN : 0969-7128_(print) 1476-5462_(electronic)
RetroNectin
In vivo persistence of genetically modified T cells generated ex vivo using the fibronectin CH296 stimulation method.
Yu SS, Nukaya I, Enoki T, Chatani E, Kato A, Goto Y, Dan K, Sasaki M, Tomita K, Tanabe M, Chono H, Mineno J, Kato I., Cancer gene therapy Vol.15 (8) p508-516.
ISSN : 0929-1903_(print) 1476-5500_(electronic)
Retroviral gene expression
Transient gene expression mediated by integrase-defective retroviral vectors.
Yu SS, Dan K, Chono H, Chatani E, Mineno J, Kato I., Biochem. Biophys. Res. Commun. Vol.368 (4) p942-947.
ISSN : 0006-291X_(print) 1090-2104_(electronic)
Glycobiology
Identification of an inducible factor secreted by pancreatic cancer cell lines that stimulates the production of fucosylated haptoglobin in hepatoma cells.
Narisada M, Kawamoto S, Kuwamoto K, Moriwaki K, Nakagawa T, Matsumoto H, Asahi M, Koyama N, Miyoshi E., Biochem. Biophys. Res. Commun. Vol.377 (3) p792-796.
ISSN : 0006-291X_(print) 1090-2104_(electronic)
Plants
Factors influencing efficiency of transient gene expression in the red macrophyte Porphyra yezoensis.
Satoru Fukuda, Koji Mikami, Toshiki Uji, Eun-Jeong Park, Toshiharu Ohba, Kiyozo Asada, Yukihiro Kitade, Hirotoshi Endo, Ikunoshin Kato, Naotsune Saga
, Plant Science, Vol.174 (3) p329-339.
ISSN : 0168-9452 (print)
ICAN method
SNP typing of aldehyde dehydrogenase2 gene with Cycleave ICAN.
Mukai Hiroyuki, et al., Molecular and Cellular Probes Vol.22 (5-6) p333-337.
ISSN : 0890-8508
2007年
Low-temperature protein expression system
Proteomic studies of an Antarctic cold-adapted bacterium, Shewanella livingstonensis Ac10, for global identification of cold-inducible proteins.
Kawamoto J, Kurihara T, Kitagawa M, Kato I, Esaki N., Extremophiles Vol.11 (6) p819-826. (United States)
ISSN : 1431-0651_(print) 1433-4909_(electronic)
Construction of a low-temperature protein expression system using a cold-adapted bacterium, Shewanella sp. strain Ac10, as the host.
Ryoma Miyake, Jun Kawamoto, Yun-lin Wei, Masanari Kitagawa, Ikunoshin Kato, Tatsuo Kurihara, Nobuyoshi Esaki, Appl Environ Microbiol. Vol.73 (15) p4849-4856 (United States)
ISSN : 0099-2240_(print) 1098-5336_(electronic)
Reductive evolution
Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea clam, Calyptogena okutanii.
Kuwahara H, Yoshida T, Takaki Y, Shimamura S, Nishi S, Harada M, Matsuyama K, Takishita K, Kawato M, Uematsu K, Fujiwara Y, Sato T, Kato C, Kitagawa M, Kato I, Maruyama T., Current biology Vol.17 (10) p881-886 (England)
ISSN : 0960-9822_(print) 1879-0445_(electronic)
ICAN method
Investigation of the Molecular Mechanism of ICAN, a Novel Gene Amplification Method.
Uemori Takashi, et al., Journal of biochemistry Vol.142 (2) p283-9 2(Japan)
ISSN : 0021-924X Print Jorunal Code : 0376600
Highly Efficient Isothermal DNA Amplification System Using Three Elements of 5'-DNA-RNA-3' Chimeric Primers, RNaseH and Strand-displacing DNA Polymerase.
Mukai Hiroyuki,et al., Journal of biochemistry Vol.142 (2) p273-281 (Japan)
ISSN : 0021-924X Print Jorunal Code : 0376600
AgriBio
Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei.
Enoki Tatsuji, et al., Journal of agricultural and food chemistry Vol.55 (15) p6013-6017 (United States)
ISSN : 0021-8561 Print Jorunal Code : 0374755
2006年
MazF
Development of anti-HIV gene therapy strategy using novel endoribonuclease, MazF (II).
Mineno Junichi(Reprint), et al.JOURNAL OF GENE MEDICINE Vol.8 (12) Page.1465 DEC 2006
ISSN : 1099-498X_(print) 1521-2254_(electronic)
Development of anti-HIV gene therapy strategy using novel endoribonuclease, MazF (I)
Chono Hideto(Reprint), et al.JOURNAL OF GENE MEDICINE Vol.8 (12) Page.1464-1465 DEC 2006
ISSN : 1099-498X_(print) 1521-2254_(electronic)
miRNA
The expression profile of microRNAs in mouse embryos.
Mineno Junichi, et al.Nucleic acids research Vol.34 (6) p1765-1771(England)
ISSN : 1362-4962 Electronic Jorunal Code : 0411011
Plants
Characterisation of BRR1, a brassinosteroid-responsive ring-finger gene from Arabidopsis.
Umeda Kahoko(Reprint), et al.Plant and Cell Physiology Vol.47 (Suppl. S) Page.S184 2006
ISSN : 0032-0781
AgriBio
Insulin-like activities of chalcone derivatives, xanthoangelol (XA) and 4-hydroxyderricin (41RD), from a Japanese herb, Angelica keiskei: Induction of adipocyte differentiation and enhancement of glucose uptake in adipocyte.
Enoki Tatsuji(Reprint), et al.FASEB Journal Vol.20 (5, Part 2) Page.A1018 MAR 7 2006
ISSN : 0892-6638
Tumor-growth inhibitory activity of the terpene compound isolated from Buna-shimeji mushroom
Mizutani Shigetoshi(Reprint), et al.Nippon Shokuhin Kagaku Kogaku Kaishi Vol.53 (1) Page.55-61 2006
ISSN : 1341-027X
2005年
MazF
Insights into the mRNA cleavage mechanism by MazF, an mRNA interferase.
Zhang Yonglong, et al.Journal of biological chemistry
Vol.280 (5) p3143-3150 (United States)
ISSN : 0021-9258 Print Jorunal Code : 2985121R
2004年
AgriBio
Isolation and characterization of a fucoidan-degrading marine bacterial strain and its fucoidanase.
Sakai Takeshi(Reprint), et al.Marine Biotechnology (New York) Vol.6 (4) Page.335-346 July 2004
ISSN : 1436-2228 _(ISSN print)
2003年
AgriBio
Structures of oligosaccharides derived from Cladosiphon okamuranus fucoidan by digestion with marine bacterial enzymes.
Sakai Takeshi(Reprint), et al.Marine Biotechnology (New York) Vol.5 (6) Page.536-544 November-December 2003
ISSN : 1436-2228 _(ISSN print)
Isolation and characterization of a fucoidan-degrading marine bacterium.
Sakai Takeshi(Reprint), et al.Marine Biotechnology (New York) Vol.5 (5) Page.409-416 September-October 2003
ISSN : 1436-2228 _(ISSN print)
Purification of sulfated fucoglucuronomannan lyase from bacterial strain of Fucobacter marina and study of appropriate conditions for its enzyme digestion.
Sakai Takeshi(Reprint), et al.Marine Biotechnology (New York) Vol.5 (4) Page.380-387 July-August 2003
ISSN : 1436-2228 _(ISSN print)
Marine bacterial sulfated fucoglucuronomannan (SFGM) lyase digests brown algal SFGM into trisaccharides.
Sakai Takeshi(Reprint), et al.Marine Biotechnology (New York) Vol.5 (1) Page.70-78 January-February 2003
ISSN : 1436-2228 _(ISSN print)
Structures of oligosaccharides derived from Cladosiphon okamuranus fucoidan by digestion with marine bacterial enzymes.
Sakai Takeshi, et al.Marine biotechnology (New York, N.Y.) Vol.5 (6) p536-544 (United States)
ISSN : 1436-2228 Print Jorunal Code : 100892712
Microarray
Development of the test method for detection of endocrine-disrupting activity using DNA microarrays.
Kondo Akihiro(Reprint), et al. Book:Toxicogenomics Page.135-140
ICAN method (Japanese)
Evaluation of the simultaneous detection system for Chlamydia trachomatis/Neisseria gonorrhoeae DNA by the isothermal and chimeric primer-initiated amplification of nucleic acids (ICAN).
Shimada Masamitsu, et al.Rinsho byori. The Japanese journal of clinical pathology Vol.51 (11) p1061-7 (Japan)
ISSN : 0047-1860 Print Jorunal Code : 2984781R
2002年
AgriBio
A marine strain of Flavobacteriaceae utilizes brown seaweed fucoidan.
Sakai Takeshi(Reprint), et al.Marine Biotechnology (New York) Vol.4 (4) Page.399-405 July-August, 2002
ISSN : 1436-2228
Oligosaccharides of agar show strong anti-inflammatory activities: By inducing hemeoxygenase-I (HO-1); suppressing the expression of inducible nitrogen oxide synthase (iNOS) and TNF-alpha.
Sagawa Hiroaki(Reprint), et al.FASEB Journal Vol.16 (4) Page.A223 March 20, 2002
ISSN : 0892-6638
ICAN method (Japanese)
Development of the detection system for Mycobacterium tuberculosis DNA by using the isothermal DNA amplification method ICAN.
Shimada Masamitsu, et al.Rinsho byori. The Japanese journal of clinical pathology Vol.50 (5) p528-532 (Japan)
ISSN : 0047-1860 Print Jorunal Code : 2984781R
2001年
DNA microarray
Application of fluorescently labeled poly(dU) for gene expression profiling on cDNA microarrays,
Meiyanto E, Mineno J, Ishida N, Takeya T., BioTechniques, (2011) 31: 406-413.
RetroNectin
Removal of inhibitory substances with recombinant fibronectin-CH-296 plates enhances the retroviral transduction efficiency of CD34+CD38- bone marrow cells.
Chono Hideto, et al.Journal of Biochemistry (Tokyo) Vol.130 (3) Page.331-334 Sep., 2001
ISSN : 0021-924X
ICAN method (Japanese)
Application of genetic diagnosis for colorectal cancer
Shimada M,
Rinsho byori. The Japanese journal of clinical pathology Vol.49 (12) p1237-1241 (Japan)
ISSN : 0047-1860 Print Jorunal Code : 2984781R
2000年
PCR
The magnetic immuno polymerase chain reaction assay for detection of Salmonella from food and fecal samples,
Ueda S, Umesako S, Mineno J, and Kuwabara Y., Biocontrol Science, (2000) 5: 25-32.
Fungous vaccine
Immunization with the Candida albicans membrane fraction and in combination with fluconazole protects against systemic fungal infections.
Mizutani Shigetoshi(Reprint), et al.Antimicrobial Agents and Chemotherapy Vol.44 (2) Page.243-247 Feb., 2000
ISSN : 0066-4804
Proteomics (Japanese)
Deblocking aminopeptidase from Pyrococcus furiosus and its application for proteomics.
Tsunasawa S, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Vol.45 (2) p186-192 (JAPAN)
ISSN : 0039-9450 Print Jorunal Code : 0413762
