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Cellartis® iPS Cell to Hepatocyte Differentiation System

使用文献

  1. 25種の幹細胞株(ヒトES/iPS細胞)で本製品を利用して肝細胞への分化誘導を確認
    One Standardized Differentiation Procedure Robustly Generates HomogenousHepatocyte Cultures Displaying Metabolic Diversity from a Large Panel of Human Pluripotent Stem Cells. Annika Asplund et al. (2016) Stem Cell Rev 12(1):90-104.
  2. Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines
    Nidal, G. et al. (2016) Stem Cells International 10.1155/2016/8648356.
  3. ヒトiPS細胞を用いた多発性肝嚢胞(Polycystic liver disease)のin vitroモデル作成において本製品を使用
    Akihide Kamiya et al., An in vitro model of polycystic liver disease using genome-edited human inducible pluripotent stem cells
    Stem Cell Research Volume 32, October 2018, 17-24.
    https://www.sciencedirect.com/science/article/pii/S1873506118302113
  4. Differentiation of human‐induced pluripotent stem cell under flow conditions to mature hepatocytes for liver tissue engineering.
    Viktoriia Starokozhko et al. (2018) J Tissue Eng Regen Med, 12:1273–1284.
  5. Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue.
    Nidal, G. et al. (2017) Physiol Genomics, 49:430–446
  6. Transcriptional, functional and mechanistic comparisons of stem cell-derived hepatocytes, HepaRG cells and 3D human hepatocyte spheroids as predictive in vitro systems for drug-induced liver injury.
    Catherine C Bell, et al., (2017) Drug Metabolism and Disposition 45:419-429.

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